Trimethoprim (Oral Route) Side Effects (2024)

Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Primsol
  2. Proloprim
  3. Trimpex

Descriptions

Trimethoprim is used to treat infections of the urinary tract. It may also be used for other problems as determined by your doctor. It will not work for colds, flu, or other virus infections.

Trimethoprim is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been used in a limited number of children 2 months of age or older, and tested in children 12 years of age or older. In effective doses, the medicine has not been shown to cause different side effects or problems in children than it does in adults.

Geriatric

Elderly people may be more sensitive to the effects of trimethoprim. Blood problems may be more likely to occur in elderly patients who are taking diuretics (water pills) along with this medicine.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dofetilide
  • Levomethadyl

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Amiloride
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Aprindine
  • Arsenic Trioxide
  • Astemizole
  • Azathioprine
  • Azilsartan
  • Azilsartan Medoxomil
  • Azimilide
  • Benazepril
  • Bretylium
  • Candesartan Cilexetil
  • Captopril
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cholera Vaccine, Live
  • Clarithromycin
  • Desipramine
  • Dibenzepin
  • Digoxin
  • Disopyramide
  • Dolasetron
  • Doxepin
  • Dronedarone
  • Droperidol
  • Enalapril
  • Enalaprilat
  • Enflurane
  • Eplerenone
  • Eprosartan
  • Erythromycin
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Fosinopril
  • Fosphenytoin
  • Gemifloxacin
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroquinidine
  • Ibutilide
  • Imipramine
  • Irbesartan
  • Isoflurane
  • Isradipine
  • Leucovorin
  • Lidoflazine
  • Lisinopril
  • Lorcainide
  • Losartan
  • Mefloquine
  • Mercaptopurine
  • Methotrexate
  • Moexipril
  • Nortriptyline
  • Octreotide
  • Olmesartan Medoxomil
  • Pentamidine
  • Perindopril
  • Phenytoin
  • Pirmenol
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Pyrimethamine
  • Quinapril
  • Quinidine
  • Ramipril
  • Risperidone
  • Sapropterin
  • Sematilide
  • Sertindole
  • Sotalol
  • Spiramycin
  • Spironolactone
  • Sultopride
  • Tedisamil
  • Telithromycin
  • Telmisartan
  • Trandolapril
  • Triamterene
  • Trifluoperazine
  • Trimipramine
  • Valsartan
  • Zofenopril
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amantadine
  • Anisindione
  • Didanosine
  • Repaglinide
  • Rosiglitazone
  • Tolbutamide

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia—Patients with anemia may have an increased chance of side effects affecting the blood
  • Kidney disease—Patients with kidney disease may have an increased chance of side effects
  • Liver disease—Patients with liver disease may have an increased chance of side effects

Proper Use

Do not give this medicine to infants or children under 12 years of age unless otherwise directed by your doctor.

Trimethoprim may be taken on an empty stomach or, if it upsets your stomach, it may be taken with food.

To help clear up your infection completely, keep taking this medicine for the full time of treatment even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

This medicine works best when there is a constant amount in the body. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times day and night. For example, if you are to take 2 doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the treatment of urinary tract infections :
    • Adults and children 12 years of age and older: 100 milligrams every twelve hours for ten days, or 200 milligrams once a day for ten days.
    • Children up to 12 years of age: Dose must be determined by the doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions

It is important that your doctor check your progress at regular visits if you will be taking this medicine for a long time. This will allow your doctor to check for any unwanted effects that may be caused by this medicine.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

If this medicine causes anemia, your doctor may want you to take folic acid (a vitamin) every day to help clear up the anemia. If so, it is important to take folic acid every day along with this medicine; do not miss any doses.

Trimethoprim may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.

Some people who take trimethoprim may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn or skin rash, redness, itching, or discoloration. When you begin taking this medicine:

  • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
  • Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
  • Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

  1. Skin rash or itching

Rare

  1. Black, tarry stools
  2. blood in urine or stools
  3. bluish fingernails, lips, or skin
  4. changes in facial skin color
  5. chills
  6. difficult breathing or shortness of breath
  7. fever with or without chills
  8. general feeling of discomfort or illness
  9. headache
  10. joint or muscle pain
  11. nausea
  12. neck stiffness
  13. pale skin
  14. pinpoint red spots on skin
  15. redness, blistering, burning, tenderness, peeling, or loosening of skin or mucous membranes
  16. redness, swelling, or soreness of tongue
  17. red skin lesions, often with a purple center
  18. sore throat
  19. swelling
  20. thickened or scaly skin
  21. unusual bleeding or bruising
  22. unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Diarrhea
  2. loss of appetite
  3. nausea or vomiting
  4. stomach cramps or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: Dec. 01, 2023

Original article: https://www.mayoclinic.org/drugs-supplements/trimethoprim-oral-route/side-effects/DRG-20066552

.

I am an expert and enthusiast assistant. I have access to a wide range of information and can provide insights on various topics. I can help answer questions, provide information, and engage in detailed discussions.

Regarding the article you provided, it discusses the drug trimethoprim, its uses, dosage forms, precautions, and potential side effects. Trimethoprim is primarily used to treat infections of the urinary tract, but it may also be used for other conditions as determined by a doctor. It is available only with a doctor's prescription. Trimethoprim is available in tablet and solution forms.

Before using trimethoprim, it is important to consider certain factors. Allergies to this medicine or any other medicines should be disclosed to the doctor. Pediatric and geriatric populations may have specific considerations when using trimethoprim. Elderly individuals may be more sensitive to the effects of trimethoprim, and blood problems may be more likely to occur in elderly patients who are taking diuretics (water pills) along with this medicine. Studies suggest that trimethoprim poses minimal risk to infants when used during breastfeeding.

Trimethoprim may interact with certain medicines, and it is important to inform your healthcare professional about all the medicines you are taking. Some medicines may not be recommended to be used together with trimethoprim, while others may require dose adjustments or additional precautions.

When using trimethoprim, it is important to follow proper usage instructions. The medicine may be taken on an empty stomach or with food if it upsets the stomach. To ensure the infection is completely cleared, it is important to take the medicine for the full time of treatment, even if symptoms improve. Missing doses should be avoided, and the doses should be taken at evenly spaced times throughout the day.

The dosage of trimethoprim will vary depending on the medical problem being treated. For the treatment of urinary tract infections, the recommended dosage for adults and children 12 years of age and older is 100 milligrams every twelve hours for ten days, or 200 milligrams once a day for ten days. The dosage for children up to 12 years of age should be determined by a doctor.

Trimethoprim may cause certain side effects, and it is important to be aware of them. Some common side effects include diarrhea, loss of appetite, nausea or vomiting, and stomach cramps or pain. Less common but more serious side effects may include skin rash or itching, blood problems, difficulty breathing, fever, joint or muscle pain, and unusual bleeding or bruising. If any of these side effects occur, it is important to contact a doctor immediately.

It is important to store trimethoprim in a closed container at room temperature, away from heat, moisture, and direct light. The medicine should be kept out of the reach of children, and outdated or no longer needed medicine should be properly disposed of.

Please note that the information provided here is a summary and should not replace the advice of a healthcare professional. It is always recommended to consult with a doctor or pharmacist for specific information about your medical condition and the use of trimethoprim.

I hope this information is helpful. If you have any further questions, feel free to ask!

Trimethoprim (Oral Route) Side Effects (2024)
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